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B p65 (NF-κ 2

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hepatocellular carcinoma 2

nuclear factor-κ 2

signal transducer and activator of transcription 6 (STAT6) 2

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-catenin 1

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Development of a dual temperature control system for isoprene biosynthesis in

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1079-1089 doi: 10.1007/s11705-021-2088-0

Abstract: dual temperature regulation system was developed through engineering and expression regulation of the transcriptionalactivator Gal4p.

Keywords： transcriptional activator     directed evolution     dynamic control     heat-shock     isoprene    

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The development of ultralightweight expanded perlite-based thermal insulation panel using alkali activator

Damla Nur ÇELİK; Gökhan DURMUŞ

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 11,   Pages 1486-1499 doi: 10.1007/s11709-022-0881-6

Abstract: In addition, an alkali activator solution was used as a binder in the mixtures.The alkaline activator solution was obtained by mixing sodium hydroxide solution (6, 8, 10, and 12 mol

Keywords： expanded perlite     alkali activator     thermal insulation panel     thermal conductivity    

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Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 195-199 doi: 10.1007/s11684-008-0037-7

Abstract: The aim of this study is to investigate the chemotactic effect of urokinase-type plasminogen activator

Keywords： chemotactic activity     receptor     uPA inhibitor     F10     chemoattractant    

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Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract:

We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.

Keywords： hepatocellular carcinoma     coexpression     module     microarray     prognosis    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Furthermore, we explored the mechanisms underlying this signature from the transcriptional and epigenetic

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Assessment and prediction of the mechanical properties of ternary geopolymer concrete

Jinliang LIU; Wei ZHAO; Xincheng SU; Xuefeng XIE

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 11,   Pages 1436-1452 doi: 10.1007/s11709-022-0889-y

Abstract: The effects of alkali content (AC) and alkaline activator modulus (AAM) on the compressive strength,

Keywords： Ternary Geopolymer Concrete (TGC)     alkaline activator modulus     alkali content     mechanical properties    

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Clinical and genetic risk factors for venous thromboembolism in Chinese population

Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 29-35 doi: 10.1007/s11684-010-0012-y

Abstract: Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, carries significant mortality and morbidity. The most important and effective way to reduce VTE incidence is to identify the patients at risk and give necessary prevention. VTE is a multifactorial and complicated disorder. Major risk factors for VTE include surgery and trauma, acute medical illness, active cancer and pregnancy. Genetic factors increase susceptibility to the disease and are useful in predicting the development of VTE. Gene-gene and gene-environment interactions alter and magnify the clinical picture in this disorder. This brief review summarizes some selected clinical and genetic risk factors for VTE based on the current research in China.

Keywords： risk factor     stroke     prothrombin     plasminogen activator inhibitor type-1     polymorphism     thrombophilia     biomarker    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: β-catenin is a key molecule involved in both cell-cell adhesion and Wnt signaling pathway. In our study, we found that, in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis B virus (HBV) X gene encoded protein, which is essential for HBV infectivity and is a potential cofactor in viral carcinogenesis. The expression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressing hepatitis B virus X protein (HBx), accompanied by destabilization of adherens junction. Reverse transcriptase PCR (RT-PCR), Northern and Western blot showed that reduction of wild-type β-catenin expression involved degradation of the protein. However, RNA interference (RNAi) and luciferase assay indicated that HBx enhanced β-catenin mediated signaling in HepG2 cells. In addition, immunohistochemical and Western blot analysis of β-catenin revealed that a decrease in the β-catenin protein level was found in 58.3% of HBV-related HCCs 19.2% of non-HBV-related tumors. Our data suggest that the expression of HBx contributed to the development of HCC, in part, by repressing the wild-type β-catenin expression and enforcing β-catenin-dependent signaling pathway, thus inducing cellular changes leading to acquisition of metastatic and/or proliferation properties.

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 475-479 doi: 10.1007/s11684-009-0086-6

Abstract: The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κ

Keywords： ulcerative colitis     signal transducer and activator of transcription 6 (STAT6)     nuclear factor-κ     B    

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Flow-Electrode Microbial Electrosynthesis for Increasing Production Rates and Lowering Energy Consumption Article

Na Chu, Donglin Wang, Houfeng Wang, Qinjun Liang, Jiali Chang, Yu Gao, Yong Jiang, Raymond Jianxiong Zeng

Engineering 2023, Volume 25, Issue 6,   Pages 157-167 doi: 10.1016/j.eng.2021.09.015

Abstract:

The development of microbial electrosynthesis (MES) for renewable electricity-driven bioutilization of CO2 has recently attracted considerable interest due to its ability to synthesize chemicals with the transition towards a circular carbon economy. However, the increase of acetate production and the decrease of energy consumption of MES using an advanced reactor design have received less attention. In this study, the total acetate production rate using novel flow-electrode MES reactors ((16 ± 1) g·m−2·d−1) was double that using reactors without powder activated carbon (PAC) amendment ((8 ± 3) g·m−2·d−1). The flow-electrode MES reactors had a Coulombic efficiency of 43.5% ± 3.1%, an energy consumption of (0.020 ± 0.005) kW·h·g−1, and an energy efficiency of 18.7% ± 1.3% during acetate production. The flow-electrode with PAC amendment could decrease the net water flux and charge transfer resistance, while had little impact on the cell voltage, rheological behavior, and acetate adsorption. In the flow-electrode MES reactors, the expression of genes involving in energy production and conversion were increased, and the increase of acetate production was found correlated with the increased abundance of Acetobacterium. The Wood–Ljungdahl pathway (WLP) and reductive citric acid cycle (rTCA) were found to be the complete pathways responsible for carbon fixation. The concentrations of acetate in the stacked flow-electrode MES reached 7.0 g·L−1. This study presents a new approach for the construction of scalable MES reactors with high-performance chemical generation and CO2 utilization.

Keywords： CO2 utilization     Biocathode     Transcriptional analysis     Microbial electrochemical technology    

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Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6 in the intestinal mucosa of patients with ulcerative colitis

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 480-484 doi: 10.1007/s11684-009-0083-9

Abstract: (CSFJC) on the expression of nuclear factor-κB p65 (NF-κB p65) and signal transducer and activator

Keywords： Flavescentis Jiechangrong capsule     nuclear factor-κ     B p65 (NF-κ     B p65)     signal transducer and activator    

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Title Author Date Type Operation

Development of a dual temperature control system for isoprene biosynthesis in

Journal Article

The development of ultralightweight expanded perlite-based thermal insulation panel using alkali activator

Damla Nur ÇELİK; Gökhan DURMUŞ

Journal Article

Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Journal Article

Assessment and prediction of the mechanical properties of ternary geopolymer concrete

Jinliang LIU; Wei ZHAO; Xincheng SU; Xuefeng XIE

Journal Article

Clinical and genetic risk factors for venous thromboembolism in Chinese population

Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Journal Article

Flow-Electrode Microbial Electrosynthesis for Increasing Production Rates and Lowering Energy Consumption

Na Chu, Donglin Wang, Houfeng Wang, Qinjun Liang, Jiali Chang, Yu Gao, Yong Jiang, Raymond Jianxiong Zeng

Journal Article

Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6 in the intestinal mucosa of patients with ulcerative colitis

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Journal Article